Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory.
Study Abstract: Small molecules that activate signaling pathways used by neurotrophic factors could be useful for treating CNS disorders. Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice. Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders.
Study Information: Maher P, Akaishi T, Abe K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A. 2006 October 31;103(44):16568-73.
The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Full Study: Originally published on October 18, 2006 by the Proceedings of the National Academy of Science of the United States of America http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637622/?tool=pubmed